Methotrexate Injection • Johns Hopkins Arthritis Center
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Methotrexate Injection • Johns Hopkins Arthritis Center
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Getting the facts straight about methotrexate
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A Critical Prescribing Lesson: Methotrexate Toxicity! The Scenario: You've correctly prescribed weekly Methotrexate. But the patient misunderstands and takes it daily, presenting to your ER with signs of toxicity. This is a medical emergency. What's the protocol? 1. The Antidote: Administer Leucovorin (Folinic Acid) Rescue immediately. It's the drug of choice. Dosing: The Leucovorin dose should be equal to or greater than the last dose of MTX taken. It's typically given IV, 6-hourly. 2. The Supp
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