Primary Lateral Sclerosis. Primary Lateral Sclerosis (PLS) is a rare, slowly progressive neurodegenerative disorder characterized by the selective deterioration of upper motor neurons, leading to muscle weakness and stiffness, primarily affecting the legs and potentially the arms and speech/swallowing muscles. | Dr. Najeeb
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Primary lateral sclerosis (PLS) is a type of motor neuron disease. A motor neuron disease affects the nerve cells in the brain that control movement. In PLS, the breakdown of nerve cells causes weakness in the muscles that control the legs, arms and tongue. Symptoms typically begin with balance trouble. People with PLS may move slowly and are clumsy. Over time, symptoms evolve to include having trouble with their hands and arms, followed by problems with chewing, swallowing and speaking. Less co
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