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Histamine intolerance is not driven by histamine intake alone. It’s driven by impaired degradation. There are two primary histamine-clearing pathways: \t1.\tDAO (extracellular, gut-dependent) \t2.\tHNMT (intracellular, methylation-dependent) While DAO gets most of the attention, HNMT is responsible for clearing histamine inside tissues, including the brain, liver, and lungs. HNMT requires SAMe, which is generated through the one-carbon (methylation) cycle. This is where COMT (catechol-O-methyltr
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