For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different, ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study presents and characterizes a Dnmt3a ...

imageimageAn evolutionarily conserved micropeptide, Sertm2, encoded by the lncRNA A730046J19Rik, promotes Etv4+ motor neuron subtype specification by GDNF, proper neurite development, and motor ...

More broadly, these findings contribute to an emerging view in which neuronal health depends on the orchestration of long-range cellular trafficking and local stress responses. By uncovering a system ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

The ability of cells to recover after the initiation of cell death pathways is only little understood. This study challenges the dogma of irreversible cell death by characterizing a programmed cell ...

Activation of cell death pathways typically leads to the irreversible destruction of the cell. However, in this issue of The ...