Dual-specificity phosphatases (DUSPs) are a subclass of protein tyrosine phosphatases (PTPs) that specifically interact with and regulate mitogen-activated protein kinases (MAPKs) by dephosphorylating ...
In a phase 1 dose-escalation study, MP0317, a CD40 agonist that targets FAP, showed tumor-localized CD40 activation with a favorable safety profile, and induced immune remodeling in the tumor ...
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