Nature

c-Myc alters the DNA damage-induced G2/M arrest in human mammary epithelial cells

Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1 ...
EurekAlert!

A novel mechanism for overexpression of c-Myc, a proto-oncogene in cancer cells

The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the ...
Nature

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

Figure 1: INI1 interacts with c-MYC in the two-hybrid system. Figure 2: INI1 directly interacts with c-MYC in vitro. Figure 3: Co-immunoprecipitation of c-MYC with INI1. Figure 4: Dominant-negative ...
ascopubs.org

c-Myc expression as a key-marker in the colorectal cancer resistance to EGFR inhibitors.

Preliminary safety and activity of perioperative triplet chemotherapy plus bevacizumab (bev) in patients with borderline resectable colorectal cancer liver metastases (CLM). Final phase II trial ...
BioWorld

Structural change in c-Myc binding site could make it druggable

Scientists at the Karolinska Institutet in Sweden have found a new region in the c-Myc oncogene that would allow the development of a binding compound to target it. Their discovery is based on a ...
BioWorld

Rationalizing the design of styrylquinolinium derivatives to bind c-Myc G-quadruplexes in breast cancer

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions ...
ascopubs.org

Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone

Herein, we demonstrate that MYC protein expression by IHC represents a rapid and inexpensive marker to identify MYC overexpression in DLBCL, including patients harboring MYC translocations, and that ...
JSTOR Daily

Myc and Mad bHLHZ Domains Possess Identical DNA-Binding Specificities but only Partially Overlapping Functions in vivo

This is a preview. Log in through your library . Abstract The opposing transcriptional activities of the basic-helix-loop-helix-leucine zipper proteins Myc and Mad, taken together with information ...
JSTOR Daily

Global Mapping of c-Myc Binding Sites and Target Gene Networks in Human B Cells

Karen I. Zeller, XiaoDong Zhao, Charlie W. H. Lee, Kuo Ping Chiu, Fei Yao, Jason T. Yustein, Hong Sain Ooi, Yuriy L. Orlov, Atif Shahab, How Choong Yong, YuTao Fu ...
Yahoo Finance

Proto Oncogene Protein C-MYC Inhibitors Industry 2021 Featuring Insights for 15+ Companies and Drugs, Including RRx-001 (EpicentRx) and WP1066 (Moleculin Biotech)

Dublin, Dec. 23, 2021 (GLOBE NEWSWIRE) -- The "Proto Oncogene Protein C-MYC Inhibitors - Pipeline Insight, 2021" drug pipelines has been added to ResearchAndMarkets.com's offering. This report ...
Mena FN

Study Of Kintor's C-Myc Degrader Published In Subsidiary Journal Of Nature

(MENAFN- PR Newswire) SUZHOU, China, March 14, 2024 /PRNewswire/ -- Kintor Pharmaceutical Limited (" Kintor Pharma ", HKEX: 9939), a clinical-stage biotechnology company developing innovative small ...
Yahoo Finance

UTR Therapeutics Publishes Landmark Preclinical Data in Frontiers in Pharmacology Supporting IND Submission for First-in-Class c-MYC RNA Therapeutic

NEW YORK, Sept. 16, 2025 (GLOBE NEWSWIRE) -- UTR Therapeutics Inc., a biotechnology company advancing a novel RNA Overwriting platform, today announced the peer-reviewed publication of preclinical ...