Transfer RNAs (tRNAs) perform a critical function in the creation of new proteins. Messenger RNA (mRNA) molecules are transcribed from active genes and are 'read' by cellular machinery, which adds new ...

The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are associated with cancer. Dihydrouridine ...

For years, scientists have been puzzled by the presence of short stretches of genetic material floating inside a variety of cells, ranging from bacteria to mammals, including humans. These fragments ...

Yeast mutants with decreased expression of a tRNA Tyr gene were obtained by selection for functional inactivation of the tyrosine-inserting ochre suppressor SUP4 and subsequent screening for ...

Ribonucleic acid (RNA) molecules are present in all living cells, with different types of RNA having different jobs. For example, messenger RNA is copied from DNA and carries instructions on how to ...

Deep in the protein translation machinery are cogs known as transfer RNAs, or tRNAs. Actually, they may be more than mere cogs, say scientists at the University of Chicago. Like other components of ...

On Tuesday, Flagship Pioneering, the major investor behind Moderna, announced yet another addition to their portfolio of RNA-curious companies. Following a year of hype around mRNA, a new company, ...

The chemical steps involved in an important cellular modification process that adds a chemical tag to some RNAs has been revealed in a new study. Interfering with this process in humans can lead to ...

With a move into Lilly Gateway Labs in Boston’s Seaport District, privately held Tevard Biosciences Inc. is ramping up development of its transfer RNA (tRNA)-based therapies to cure everything from ...

Instead of fixing one of the many genes that can be mutated, the technique addresses a type of mutation they share, a stop codon that cuts off protein production too soon.