For the smart thermostat I have (an ecobee3), the answer is no. It does support two stage heating and cooling systems, but only a single zone. I think the Nest is the same. I have cheap Honeywell's, ...

The Z-300-HC-MS two-stage heat/two-stage cool zone control panel works with two-stage thermostats, which permits up-staging based on temperature instead of upstaging based on time delay, says the ...

Description: Due to its ability to fire at two distinct rates, this product provides energy-efficient heat that can effectively adjust to sudden high heat-loss conditions or economically maintain ...