A model of the genome is described which relates certain observations on the additive nature of enzyme activity to observations on the quantitative genetics of fitness traits. The model assumes that ...

Mathematical modeling helps researchers to understand how enzymes in the body work to ensure normal functioning. The models also can show how genetic mutations alter the enzymes' behavior in ways that ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the attention of scientists like me. Consider muscle movement. Your body ...

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system. Enzymes usually clear these nucleic acids before they cause an issue, but when these ...

The rational design of enzymes is an important goal for both fundamental and practical reasons. Here, we describe a process to learn the constraints for specifying proteins purely from evolutionary ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the attention of scientists like me. Consider muscle movement. Your body ...