HECT E3s feature the C-terminal HECT domain, which assumes a bilobal architecture, with the N-terminal lobe containing the E2-binding domain and the C-terminal lobe harboring the catalytic cysteine ...

Understanding its role has enabled Tansey and colleagues to more comprehensively grasp how ubiquitin functions. They have discovered that Asr1 "glues" ubiquitin on to specific spots in the DNA-copying ...

Our understanding of how ubiquitin regulates cellular functions has greatly expanded in the past several years, spurred by discoveries of protein families involved in ubiquitin conjugation and ...

Researchers at TMIMS have revealed that PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria ...

Ubiquitin is a prototype of a family of isostructural conserved proteins that are responsible for a variety of processes in eukaryotic cells 1. These structurally-conserved proteins covalently bind to ...

When proteins within the body get tagged with a molecule called ubiquitin, they are essentially marked for destruction. But they can be saved; a deubiquitinase enzyme can remove the ubiquitin, keeping ...

Ubc13, a ubiquitin-conjugating enzyme (Ubc), requires the presence of a Ubc variant (Uev) for polyubiquitination. Uevs, although resembling Ubc in sequence and structure, lack the active site cysteine ...

The COP9 signalosome (CSN) is an evolutionarily conserved multiprotein complex that mediates the repression of photomorphogenesis in the dark in Arabidopsis through the degradation of transcription ...

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and ...

As we age, the composition and function of proteins in the brain change, affecting how well our brain performs later in life—influencing memory, responsiveness, and the risk of neurodegenerative ...

Leishmaniasis belongs to the class of neglected tropical diseases (NTDs) that particularly affect people in the poorest tropical regions of the world. NTDs are less studied and therapeutically ...