The vast majority of cancer cells have too few or too many copies of some chromosomes, a state known as aneuploidy. But for decades, researchers have debated whether aneuploidy promotes the growth of ...

New research shows that the male X chromosome is silenced in some types of cancer. Researchers evaluated how a certain gene affects the male X chromosome in cancer cells. Experts explain why these new ...

Researchers at Cardiff University have uncovered how a particularly severe form of DNA damage arises—shedding new light on mutation processes that contribute to cancer and inherited genetic conditions ...

The loss of the Y chromosome in tumour cells is linked to poor outcomes for people with cancer 1, but this genetic alteration might also compromise immune cells that would otherwise fight the disease.

"Inter-chromosome connections may prove to be an integral and pervasive governing feature of chromosome organization in many types of human cells," says Stowers Investigator Jennifer Gerton, Ph.D., ...

Robertsonian chromosomes are large chromosomes that form when the long arm of a chromosome breaks and fuses with another chromosome. They are the most common type of chromosome rearrangement in humans ...

Scientists describe how a phenomenon known as 'chromothripsis' breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth. Cancer is one of the world's greatest ...