The article about using animal models in human health applications was informative (C&EN, March 20, page 30). The predominant use of male rodents in many studies was shown to raise serious questions ...

The application of Cox proportional hazards (CoxPH) models to survival data and the derivation of hazard ratio (HR) are well established. Although nonlinear, tree-based machine learning (ML) models ...

Time and motion studies can be a useful way to gather real world evidence of a medical intervention's value. When the efficiency of a drug, medical device, or intervention is the outcome of interest, ...

Data used to inform NICE guidance should be reported transparently and be of good provenance and fit for purpose in relation to the research question. The primary aims of this section of the framework ...