Recently, the stromal invasion grading system was proposed for small adenocarcinomas of ≤2.0 cm. The system is based on the presence or absence of a fibrotic focus, and the extent of invasion into the ...

Donald F Gleason in 1966 created a unique grading system for prostatic carcinoma based solely on the architectural pattern of the tumor. 1, 2 Another innovative aspect of this system was, rather than ...