Interaction specificity is a required feature of biological networks and a necessary characteristic of protein or small-molecule reagents and therapeutics. The ability to alter or inhibit protein ...

Computational protein design—the automated search for amino acid sequences with defined three-dimensional structures—opens exciting possibilities for the engineering of biomolecules with desired ...

Large prospective cohorts originally assembled to study environmental risk factors are increasingly exploited to study gene-environment interactions. Given the cost of genetic studies in large samples ...

In some experimental situations, there is a natural grouping of factors. Prior knowledge may indicate that active two-factor interactions only occur within groups of factors. Designs of variable ...

Emerging interactive technologies are rapidly transforming the ways in which we work, play, communicate, and learn. Research on tangible interaction attempts to blur the line between digital ...