JSTOR Daily

Amphigonalia bispinosa, a New Leafhopper Species from California and the Replacement Vector Species for Amphigonalia severini (DeLong) (Homoptera: Cicadellidae: Cicadellinae)

A new species of leafhopper, Amphigonalia bispinosa, is described and is the replacement vector species for A. severini (DeLong) which had been previously misidentified. Distribution of both species ...
Nature

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Figure 1: Insertion of a traffic light reporter into the AAVS1 locus of HEK293 cells and suppression of the NHEJ pathway. To assess whether a point mutation can be corrected in a tumor cell line, we ...
ALZFORUM

Gba1 L444P KI Mouse (JAX)

L444P KI mice were generated using a loxP replacement vector, resulting in the insertion of a point mutation of leucine to proline (L444P) in exon 10 of the Gba1 gene (Ginns et al., 2014). These Gba1 ...
The American Journal of Managed Care

FDA Approves Gene Therapy Onasemnogene Abeparvovec for Broader SMA Population

Onasemnogene abeparvovec-brve is the first gene replacement therapy approved for SMA patients aged 2 years and older, expanding access beyond infants. Phase 3 trials demonstrated significant motor ...