Maturation of pre-mRNA by capping, splicing, and cleavage and polyadenylation can occur co-transcriptionally at the gene; the substrate for these reactions is therefore a growing nascent RNA chain.

Considerable evidence indicates that the processes involved in synthesizing mature messenger RNA in the eukaryotic nucleus are intimately coupled to one another. RNA polymerase II plays an important ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

This is a preview. Log in through your library . Abstract The numerous steps in protein gene expression are extensively coupled to one another through complex networks of physical and functional ...

The Lai lab uses an integrated approach to study selected topics in mRNA processing and modification, including alternative polyadenylation, circularization and RNA methylation. As a core member of ...

Recent research on Arabidopsis thaliana flowering may sow the seed of new connections between plant and human reproduction. Gordon Simpson and Caroline Dean at the John Innes Center in Norwich, UK, ...

This study is led by Professor XiaoqinLiu (Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences, Shangdong, China). The authors explored ...

Similar to a newborn human, nascent RNA transcripts need a lot of coddling before they realize their purpose in life (that is, translation into protein). It takes a village of RNA-binding proteins to ...