Bone acquisition and remodeling depend on the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. During postnatal development, the activity and lifespan of osteoblasts ...

Bone cells known as osteoblasts were recently shown to have a role in controlling the biochemical reactions that generate energy. Researchers have now identified Atf4 as the regulatory gene that ...

Endothelial-to-Osteoblast Conversion (EC-to-OSB) regulates bone formation and homeostasis via the Kindlin-2/Piezo1/TGFβ/Runx2 axis. Reduced Kindlin-2 in endothelial ...

Studies of patients with osteopetrosis, a condition characterized by increased bone mass and mineralization resulting from osteoclast dysfunction, have resulted in identification of many critical ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...

Researchers from the University of Leipzig and Shandong University have recognized GPR133, a receptor in bone-forming cells, ...

A cellular protein whose normal function appears to suppress bone formation may be a potential new target for treating osteoporosis, suggests a collaborative study led by Weill Cornell Medicine and ...

Interdisciplinary approaches in developmental biology have revealed how cells build the embryonic bones of the skull vault ...

Bone cells known as osteoblasts were recently shown to have a role in controlling the biochemical reactions that generate energy via secretion of the molecule osteocalcin. Gerard Karsenty and ...