When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

DNA replication origins serve as sites of replicative helicase loading. In all eukaryotes, the six-subunit origin recognition complex (Orc1-6; ORC) recognizes the replication origin. During late ...

Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogenous and ...

A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has unveiled the structure and mechanism of proteins that are highly overexpressed in various ...

Researchers studied an error mechanism in DNA replication, and noticed that some errors create palindromes that can fold into hairpin structures. The complexity of ...

Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

Inactivation of mismatch repair (MMR) causes inherited and sporadic cancers 1. These tumours exhibit microsatellite instability (MSI) - length alterations within short repeats. MSI is a diagnostic and ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...

In a recent review published in Mutation Research/Reviews in Mutation Research, researchers described potential mechanisms of coronaviruses that could lead to deoxyribonucleic acid (DNA) damage and ...