Scientists investigated the efficiency of splicing across different human cell types. The results were surprising in that the splicing process appears to be quite inefficient, leaving most intronic ...

In the genome, genes that code for protein are often divided into sections called exons, which are separated by spacers called introns. When a region of DNA is transcribed into messenger RNA (mRNA) or ...

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been ...

Each mRNA transcript contains coding regions, known as exons, and noncoding regions, known as introns. They also include sites that act as signals for where splicing should occur, allowing the cell to ...

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular process ...