Thanks to a software update, you can now program select new and older Logitech keyboards and mice to perform complex tasks with a click or a tap.

Macworld At a glance Expert's Rating Pros ・Sturdy, comfortable design ・Horizontal and vertical scrolling wheel ・Programmable ...

I know this can be done in most games. however to replace some of the missing buttons you'd have to remap the extra mouse buttons on your mouse to keyboard keys for every different game.