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AI model predicts drug toxicity using differences between animal models and humans

In the UK, there was a case where TGN1412, an immunotherapy under development, triggered a cytokine storm within hours of administration to humans, leading to multiple organ failure. Another example, ...

VivoSim Platform Predicts Gastrointestinal Toxicity (Diarrhea) in an AI Model Trained on Human Intestinal Model Results – Without Animal Testing

VivoSim Labs, Inc. (Nasdaq: VIVS) (the “Company” or “VivoSim”), a provider of next-generation New Approach Methodologies (NAMs) for preclinical safety, today announced the availability of an AI ...
Nasdaq

VivoSim Labs, Inc. Showcases NAMkind™ Platform's Industry-Leading Liver Toxicology Prediction at Digestive Disease Week Conference

VivoSim Labs' NAMkind™ platform shows 87.5% predictive accuracy for liver toxicity, enhancing drug safety and reducing development costs. VivoSim Labs, Inc. announced the successful performance of its ...
News Medical

Optimizing in vitro models for predicting human renal toxicity

When rats and dogs were dosed with an active component, the client noticed their pharmacodynamics in vivo differed. The client wanted to understand the mechanism underlying these differences and ...
GEN

Biologics Drug Development Gets an Upgrade with Humanized Animal Models

While humanized animal models are relatively new to drug development compared to their non-humanized counterparts, they are critical tools in the landscape of biologic drug development. Their success ...