Scientists have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat with medication. The computational tool is ...

A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability In a recent study published in Nature, researchers used ...

Postdoctoral researcher Urmila Sehrawat discusses her work at Memorial Sloan Kettering Cancer Center on translational machinery and novel cancer therapeutics.

Genetic diseases that result from truncated proteins can be targeted by so-called nonsense suppression therapies—drugs that prevent protein translation from terminating prematurely. A new ...

A study in the journal Pharmaceuticals has uncovered how specific genetic mutations in α 2 δ-1 and α 2 δ-3 proteins linked to autism spectrum disorders (ASD) alter neuronal functionality. These ...

Scientists at the Baylor College of Medicine say they have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called ...

Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the ...

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

A new study found that a single mutation to the hemagglutinin protein of an H5N1 virus isolated from a dairy worker in Texas this spring switched the protein’s binding specificity from avian- to human ...

Scientists from Cleveland Clinic and Cornell University have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat ...