Learn how small mutations in non-coding DNA can alter sex development in rodents.

Humans have about 3 billion DNA bases in their genetic makeup. However, most of it does not encode for protein.

Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

A single DNA letter, inserted into a stretch of the genome that doesn’t code for any protein, was enough to turn genetically ...

Typically, female mouse embryos with two X chromosomes develop ovaries because a gene called Sox9 is suppressed. In male ...

A study shows that changes in noncoding genes can trigger autoimmune diabetes in infants by affecting hundreds of immune-related genes, expanding understanding of genetic disease.

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

The human genome contains about 20,000 protein-coding genes, but that only accounts for roughly two percent of the genome. For many years, it was easier for scientists to simply ignore all of that ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...