Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem cell-derived hepatic organoids, report researchers from Japan. These ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

A novel 3D cell culture method has been developed that encourages liver progenitor cells to self-organize and form blood vessel networks for the first time. The development of accurate liver organoids ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. The ...

The aging and failure of cells that occurs when the liver is damaged can spread to other organs, suggests a new study in mice and humans from researchers at UCL, the University of Edinburgh and the ...

Fifteen years ago, doctors in Europe noticed a remarkable thing happening in people with chronic hepatitis B infections. When patients went off their medications, the virus started to come back — and ...

Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.