An international team, including scientists from Leipzig University, has gained important new insights into the regulation of ...

Study identifies impaired ER-to-golgi ceramide transport as a key regulatory node underlying senescence-associated sphingolipid remodeling.

Now, in a study published March 30 in Cell Chemical Biology, UB scientists have shed light on one such stressor, showing that ...

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

What is the endoplasmic reticulum? The endoplasmic reticulum is the single largest membrane-bound organelle found inside eukaryotic cells. Its complex structure containing tubules, sheets, and ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...

Protein sorting in the secretory pathway is essential for cellular compartmentalization and homeostasis in eukaryotic cells. The endoplasmic reticulum (ER) is the biosynthetic and folding factory of ...

Ceramide buildup due to faulty transport triggers stress responses that lock cells into senescence, revealing a potential ...

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.