SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli. The ...

Researchers uncover a previously unrecognized mechanism that may accelerate polycystic kidney disease. For people with polycystic kidney disease (PKD), life can be a constant cycle of symptoms: aches ...

Roughly one million people die of untreated kidney failure, worldwide, each year. Despite the major personal and economic burden, only a few new approaches have been deployed to treat or cure kidney ...

THE ever-increasing number of case reports of renal complications in sulfonamide drug therapy indicates that neither the mechanism of their production nor the means of preventing them is yet ...

Researchers at the University of Tsukuba have developed a novel mouse model that allows them to induce dysfunction in only one kidney. Using this model, they uncovered the molecular mechanisms behind ...

A group of Northwestern University researchers has identified what they believe is a built-in biological mechanism that prevents kidney damage in the early stages of diabetes associated with obesity.

(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate ...

A new study from Aarhus University demonstrates that a protein known for treating cardiovascular diseases also affects a mechanism in the kidney that reabsorbs proteins. This finding could lead to new ...

There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal ...

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2 ...

University of Texas at Dallas scientists have discovered a previously unknown "housekeeping" process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and ...