A recent study utilizing cryo-EM advances our understanding of how bacterial immune systems function and reveals new aspects of CRISPR-Cas biology. Researchers at Vilnius University (Lithuania) have ...

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated proteins (Cas) system is a bacterial defense mechanism that uses RNA-guided enzymes to cut specific sequences ...

The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the ...

(a) Utilizing HCR and CRISPR-Cas12a double amplification technique, a highly sensitive apta-HCR-CRISPR method was devised for the detection of TEV protein. (b) A novel CRISPR-Cas12a/Cas13a approach, ...

The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the emphasis has been on its underlying mechanisms and nucleases. In contrast, ...

Investigating small protein inhibitors of CRISPR–Cas — an adaptive immune system in bacteria — has led to the discovery of a mechanism for inhibiting a large macromolecular complex. AcrIF25, an ...

Scientists have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors. A revolution in biomedicine is currently underway, driven ...

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins are core components of fast-evolving therapeutic gene editing tools. Scientists have used CRISPR ...

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage. Type V CRISPR-Cas (Cas12) systems, in particular, ...

Researchers have discovered a handful of new CRISPR-Cas systems that could add to the capabilities of the already transformational gene editing and DNA manipulation toolbox. Of the new recruits, one ...