Northwestern Medicine investigators have uncovered new insights into how intercellular "glue" functions to enable interactions between cells, as detailed in a study published in Nature Communications.
MSK immunologist Dr. Andrea Schietinger and colleagues found that a 'triad' of immune cells is required to kill cancer cells. The discovery could alter the way doctors administer immunotherapies.
Cell-to-cell junctions were visualized by ZO1-GFP, and the dynamics of cell junctions were captured by movies. When the cells indicated by * were spontaneously stretched, a continuous belt of cell ...