For example, inflammatory caspase-1 has been implicated in causing autoimmune diseases; drugs blocking the activation of Caspase-1 have been used to improve the health of patients. Additionally, …

May 5, 2025 · Traditionally, caspases are classified as either apoptotic (caspase-2, -3, -6, -7, -8, -9, and -10) or inflammatory (caspase-1, -4, -5, and -11).

Accordingly, caspases have been broadly classified by their known roles in apoptosis (caspase-3, -6, -7, -8, and -9 in mammals), and in inflammation (caspase-1, -4, -5, -12 in humans and caspase-1, -11, …

Jul 24, 2025 · Caspase activation in programmed cell death unfolds through a coordinated cascade. Caspases are initially present in cells as inactive precursors called procaspases.

May 19, 2025 · The conservation of caspase-mediated pathways across species highlights their essential role in development and tissue homeostasis. Recent research has identified new caspase …

Therapeutic interventions that involve the caspase cascade have long been a goal of many pharmaceutical companies because dysregulated caspase activity (and therefore apoptosis) is an …

Jun 24, 2025 · Apoptosis: caspase-8 (extrinsic pathway) and caspase-9 (intrinsic pathway) play crucial roles in apoptosis by cleaving and activating executioner caspases, such as caspase-3 and caspase-7.

Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. The caspase members of this clan are only found in animals, and most of …

Jun 23, 2025 · Discover how caspase activity, a precise enzyme function, regulates the cellular lifecycle. Understand its critical role in maintaining tissue homeostasis and…

Accordingly, caspases have been broadly classified by their known roles in apoptosis (caspase-3, -6, -7, -8, and -9 in mammals), and in inflammation (caspase-1, -4, -5, -12 in humans and caspase-1, -11, …