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Aging brains show surprising mix of decline and adaptation

Learn more about the new study, which highlights the importance of analyzing brain structure and connectivity simultaneously.
C&EN

Investigating the Structural and Functional Consequences of Pathogenic SNPs on Human VEGFA Dimer: Insights from Molecular Dynamics Study

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Vascular endothelial growth factor A (VEGFA) is a key regulator of angiogenesis. It ...
Frontiers

Neuroadaptive changes in brain structural–functional coupling among pilots

Background: Investigating the neural mechanisms underlying pilots’ brains is crucial for enhancing aviation safety. However, prior research has predominantly focused on identifying structural and ...
Self

What Is Functional Medicine—and Should You Ever Try It?

Generally speaking, it’s usually a win when things are functional. Functional fitness, for example, focuses on movement patterns you use in everyday life. Functional fashion might bring to mind ...
eLife

Canonical neurodevelopmental trajectories of structural and functional manifolds

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. In this study, the authors advance our understanding of ...
C&EN

Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity

Janus kinase 2 (JAK2) plays a critical role in orchestrating hematopoiesis, and its deregulation leads to various blood disorders, most importantly myeloproliferative neoplasms (MPNs). Ruxolitinib, ...
Frontiers

Editorial: Structural understanding of the functional consequences of missense mutation

Missense mutations are genetic changes that modify the amino acid sequence of proteins. Recent advances in predicting the structure of proteins have made significant strides, yet much is still unknown ...