The Warburg effect describes how cancer cells switch from oxidative phosphorylation to glycolysis even in oxygen-rich ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Histone modifications, including methylation, acetylation, lactylation, phosphorylation, ubiquitination, SUMOylation, ADP-ribosylation, and crotonylation, critically regulate tumor-associated ...

Although not yet adopted by any state, the Uniform Mortgage Modification Act aims to clarify and simplify the law governing mortgage modifications by creating brightline safe harbors for common ...

The latest chemistry news, including important research advances, business and policy trends, chemical safety practices, career guidance, and more. The work was led by Ian Maze, a neuroepigeneticist ...

Introduction: Cardiac hypertrophy is characterized by significant metabolic changes, notably an increase in glycolysis. Histone lactylation, a post-translational modification influenced by the ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment ...

Eed-flox mice were backcrossed to C57BL/6 for more than 7 generations (24). CD4-Cre transgenic mice were crossed with Eed-flox mice to generate Eed conditional knockout (cKO) mice (25). C57BL/6 (Ly5.2 ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. By mapping H3K4me2 in ...

The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt, and high blood pressure (BP), which led to the major genetic-based experimental model of hypertension. BP, a ...