The 2025 Monday Night Football schedule has some pivotal NFL matchups that could have a big impact on the NFL season. Including the MNF game on Dec. 22. From Week 1 through Week 17, ESPN and/or ABC ...

The last chance to make a Week 16 NFL SGP comes on 'Monday Night Football' as the San Francisco 49ers visit the Indianapolis Colts (4.5, 46.5) at 8:15 p.m. ET. Both teams are on streaks, as San Fran ...

The San Francisco 49ers will face the Indianapolis Colts for a Monday Night Football game. The Week 16 matchup is scheduled for Monday, Dec. 22, 2025, at 8:15 p.m. at Lucas Oil Stadium. The game will ...

Who will win on Monday Night Football in NFL Week 16? The Arizona Republic is predicting a 20-17 win for the 49ers over the Colts in the NFL Week 16 Monday Night Football game. Jeremy Cluff writes: ...

It's been a wild 2025 NFL season, with some absolutely crazy games this year and still no real true contender emerging in the standings. But if you're here, you might be wondering: Is there any NFL ...

Next Gen Stats Insight for 49ers-Colts (via NFL Pro): Brock Purdy has a 144.6 passer rating when targeting George Kittle this season, the highest between any QB-receiver duo in the last five seasons ...

The 'Monday Night Football' matchup between the Colts and 49ers at 8:15 p.m. ET features the top two Fantasy running backs in the NFL DFS player pool. Jonathan Taylor and Christian McCaffrey rank ...

The Monday Night Football matchup for Week 16 features an inter-conference matchup between the 49ers and Colts. Our NFL player prop projections have identified the best MNF prop values for tonight, ...

Could today be your lucky day when you become the next Powerball millionaire? The Powerball jackpot is an estimated $1.6 billion with a cash option of $735.3 million for Monday night's drawing, ...

The San Francisco 49ers will play the Indianapolis Colts for Monday Night Football. The Week 16 game is scheduled for 8:15 p.m. on Monday, Dec. 22, 2025. Viewers can watch the game on ESPN or stream ...

An Indianapolis team with 44-year-old Philip Rivers at quarterback will try to snap a four-game losing streak and get back in the playoff chase when it takes on a San Francisco 49ers team with hopes ...