cirm.ca.gov

Cardiac Development at a Single-Cell Resolution.

Mammalian heart development is a complex process. Recent advances in using stem-cell-derived cardiac progenitor cells along with advanced genetic methods are described that will lead to a better ...
cirm.ca.gov

The cardiac conduction system: History, development, and disease.

The system in the heart that controls muscle contraction is discussed. Known diseases relating to the development of heart contraction and clinical approaches to correct defects in heart contraction ...
cirm.ca.gov

Protocol for vibratome sectioning, immunofluorescence, and S-phase labeling of inner ear organoids.

This study describes methods for analysis of inner ear sensory hair progenitor cells isolated from stem-cell-derived organoids. This enables the visualization of cell and tissue morphologies within ...
cirm.ca.gov

CRISPR activation for SCN2A-related neurodevelopmental disorders.

Serena Tamura, Andrew D Nelson, Perry W E Spratt, Elizabeth C Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S ...
cirm.ca.gov

Deep learning the dynamic regulatory sequence code of cardiac organoid differentiation.

Eyal Metzl-Raz, Ryan Zhao, Salil Deshpande, Jackson Powell, Elizabeth G Porter, Yassine Zouaghi, Betty B Liu, Samuel H Kim, Immanuel Abdi, Ivy Evergreen, Megha Agarwal, Maya U Sheth, Joshua Rico, ...
cirm.ca.gov

A human-specific regulatory mechanism revealed in a pre-implantation model.

Pre-implantation events in human development are difficult to study due to ethical concerns. This work utilizes a human stem-cell-based blasted model to test the genetic regulation of implantation ...
cirm.ca.gov

CIRM approves over $160M to support preclinical and clinical research, advances education opportunities and access to clinical trials

South San Francisco, CA, December 11, 2025 – The California Institute for Regenerative Medicine (CIRM) governing board today approved funding of over $160 million for 16 new research awards to develop ...
cirm.ca.gov

CIRM approves $73 million in awards for discovery research

South San Francisco, CA, September 25, 2025 – The California Institute for Regenerative Medicine (CIRM) has approved awarding more than $73 million across 23 grants to support discovery research ...
cirm.ca.gov

CIRM Announces Leadership Transition

South San Francisco, CA, Nov. 7, 2023– The California Institute for Regenerative Medicine (CIRM), the world’s largest institution dedicated to regenerative medicine, announced today that Maria T.
cirm.ca.gov

California’s Stem Cell Agency Invests in Stem Cell-Based Therapies Targeting Sickle Cell Disease and Cancer

February 22, 2018 – Oakland, CA The California Institute for Regenerative Medicine (CIRM), California’s Stem Cell Agency, today invested almost $10 million in stem cell research targeting sickle cell ...
cirm.ca.gov

CIRM Approves New and Updated Funding Programs, Awards $26.5 Million for Clinical Research and Development

South San Francisco, CA, March 27, 2025 — The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine, approved new and ...
cirm.ca.gov

CIRM Awards Nearly $100 Million to Boost Discovery, Translational, and Clinical Disease Research

South San Francisco, CA, January 30, 2025 – The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine, has awarded nearly ...