Gut

CD48 is a novel immune checkpoint on tumour‐associated macrophages in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...
Opinion
GutOpinion

Road to IBD prevention in the Global South: a conceptual framework modelling from non-communicable diseases

IBD is rising worldwide and is now a global disease. With the expanding armamentarium of medical therapies, including biologics and small molecules, there is a decline in hospitalisation rates and IBD ...
Gut

Recovery of HBV-specific B cell function after discontinuation of nucleos(t)ide analogue therapy: new insight and future challenges

In hepatitis B virus (HBV) infection, the capacity to mount a functional virus-specific T-cell response has long been considered the principal, if not the sole, immunological determinant of viral ...
Gut

Proton pump inhibitors use and risk of inflammatory bowel disease in children

A recent randomised controlled trial showed that proton pump inhibitors (PPIs), compared with histamine-2 receptor antagonists (H2RAs), induce greater gut microbiome alterations and oral-to-gut ...
Gut

Global guidelines on diverticular disease of the colon: the Fiesole Consensus report

Introduction Colonic diverticulosis is the most common structural abnormality of the colon in developed countries, with an increasing global prevalence. Approximately 20–25% of affected individuals ...
Gut

Role of A2 beta casein in milk-induced eosinophilic oesophagitis: novel in-vivo and in-vitro findings

We read with interest the article by Santacroce about personalised medicine in eosinophilic oesophagitis (EoE) and the ...
gut.bmj

Individualised therapy is more cost-effective than dose intensification in patients with Crohn’s disease who lose response to anti-TNF treatment: a randomised, controlled trial

4 Department of Hepatology and Gastroenterology V, Aarhus Hospital, Aarhus, Denmark 5 Department of Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark 6 Department of Medical Gastroenterology S, ...
gut.bmj

Real-time unblinding for validation of a new CADe tool for colorectal polyp detection

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis

1 Wolfson Unit for Endoscopy and Department of Gastroenterology, St Mark’s Hospital, Harrow, UK 2 Department of Gastrointestinal Histopathology, St Mark’s Hospital, Harrow, UK Correspondence to: Dr B ...
gut.bmj

Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers

Background We conducted an integrated cross-species spatial assessment of transcriptomic and metabolomic alterations associated with progression of intraductal papillary mucinous neoplasms (IPMNs), ...
gut.bmj

Pathobiology of liver fibrosis: a translational success story

Correspondence to Scott L Friedman, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave., Room 11-70C, Box 1123, New York, NY 10029-6574, USA; ...
gut.bmj

Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer

Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, the regulatory effect of CXCL8 on immune ...