Most cancer treatments are based on using the maximum tolerated dose of a drug to kill as many cancer cells as possible. While this approach has led to patients achieving good responses to therapy, ...

Researchers demonstrate how mathematical modeling combined with dynamic biomarkers can be used to characterize metastatic disease and identify appropriate therapeutic approaches to improve patient ...

Repetitive transcranial magnetic stimulation (rTMS) and other targeted, noninvasive neuromodulation approaches offer promise for treating neuropsychiatric conditions. These techniques work by ...

Cell and gene therapies are exciting new modalities that have the potential to treat, and even cure, a range of diseases that may not be possible with small molecules or monoclonal antibodies. However ...

Nanoparticle-mediated hyperthermia for cancer therapy is a growing area of cancer nanomedicine because of the potential for localized and targeted destruction of cancer cells. Localized hyperthermal ...

Spinal muscular atrophy (SMA) is a rare but serious neuromuscular disorder that causes worsening muscle weakness. SMA is a genetic, or inherited, disorder caused by a change in the SMN1 gene that ...

Chimeric antigen receptor (CAR) T-cell therapy shows significant potential in treating various human cancers. Unfortunately, researchers have faced difficulty in adapting this therapy to target solid ...

The spectrum of metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from simple lipid accumulation in the human liver, to steatohepatitis with inflammation, fibrosis, cirrhosis, ...