PHILADELPHIA -- Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does ...

Scientists have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei. Previously, microRNAs were mainly thought to be found in cytoplasm. The ...

Researchers have found that levels of methylated microRNA were significantly higher in tissue and serum from cancer patients compared with that from normal controls. Specifically, methylation levels ...

Comparative effectiveness of treatment strategies for urothelial cancer of the bladder (UCB) with clinical lymph node involvement (cN+). Anti-tumor activity, safety and pharmacokinetics (PK) of AGS15E ...

Please provide your email address to receive an email when new articles are posted on . The Nobel Assembly at Karolinska Institutet in Sweden announced the honor today. Victor R. Ambros, PhD, and Gary ...

Potential of Field Is Catalyst for Emerging Diagnostic and Therapeutic Strategies As key regulators of gene expression and cellular machinery, microRNAs may be the most significant discovery in ...

Nibbler (Nbr) is a 3′-to-5′ exoribonuclease whose catalytic 3′-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional ...

This is a preview. Log in through your library . Abstract Diverse viruses encode regulatory RNAs called microRNAs (miRNAs). Despite much progress, the functions of the majority of viral miRNAs remain ...

In the October15th issue of G&D, Dr. Fen-Biao Gao and colleagues at UCSF report that microRNA-9a (mir-9a) regulates neural development in the fruit fly, Drosophila. Using loss-of-function analysis, Dr ...

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...