Tissue-resident macrophages are present in virtually every organ of the body to execute a variety of vital functions and ensure tissue integrity and functionality. Single-cell RNA sequencing ...

Tissue-resident macrophages are crucial players in the immune system, acting as the first line of defense and maintaining tissue homeostasis by responding to various environmental challenges and ...

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapeutic options. Despite ...

Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial. In ...

Macrophages and other immune cells are the natural frontline immune warriors of our body, defending the body against invading pathogens and cancer cells. Yet despite their innate "combat" capabilities ...

Even its name is a testament to how enigmatic the tingible macrophage has been. Tingible, which means stainable, certainly gives no clues to its functions – but was, at least, one thing that was known ...

Sepsis is a fatal syndrome characterized by life-threatening organ dysfunction originating from a chaotic and unchecked innate immune response to infection. Notably, macrophages are the master ...

Within tumors in the human body, there are immune cells (macrophages) capable of fighting cancer, but they have been unable ...

Ulcerative colitis (UC) is one of the most common inflammatory bowel diseases, a lifelong condition that can cause chronic inflammation and ulcers in the lining of the large intestine. This can lead ...

Tumors contain macrophages, immune cells capable of fighting cancer, but their function is suppressed by the tumor, ...