Autophagy leads to the lysosomal degradation of cytosolic components and organelles. The best understood role for autophagy is directing the removal of damaged or unwanted products. Autophagy can be ...

Nutrient deprivation inhibits mTORC1 and activates AMPK, which then dephosphorylates or phosphorylates ULK1 at different sites, leading to the activation of the ULK complex and initiation of the ...

Mutations in the proapoptotic BAX gene are associated with defective DNA mismatch repair and altered tumor growth rates in human colon cancers The metabolic fragility of cancer cells is magnified with ...

A team of researchers led by Osaka University unravel a tangle of pathways involving calcium, lipids, and the degradation of damaged lysosomes that is essential for preventing crystal-induced kidney ...

Recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses, hijacks various host cell machinery such as autophagy for replication and ...