Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still ...

There is perhaps no more fundamental property of life than change, both with respect to personal experience and, as the basis of evolution, to the nature of biology itself. The constant genetic ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

The story of cancer is, largely, one of broken genes. The valiant tumor suppressor, defender of cellular integrity, maimed and enfeebled. The conniving oncogene, hyper-activated, allowed to run wild ...

Researchers identify hundreds of candidate histone proteins in bacteria, including one with an unusual way of binding to DNA. Now, Warnecke and colleagues are challenging the idea that these ...